Head coach Danny Wilson named a squad containing a blend of youth and experience for the Rodney Parade clash, with the intention to give all players an opportunity during pre-season.
They came up against a close to full-strength Newport Gwent Dragons outfit, who beat RGC 1404 last weekend, and got off to a slugglish start.
Wales’ Capital Region trailed 31-7 at the interval with Lewis Jones scoring the sole try to the Dragons’ four, which were scored in the first 20 minutes.
The Blues improved as the game went on and clawed their way back with tries from debutant Steven Shingler and Josh Navidi but they had left too much to make up.
The hosts dominated the early territory and Nick Macleod opened the scoring on four minutes when he slotted a simple penalty.
Wilson’s men responded but the ball was spilled in midfield and the door was open for the Dragons to attack.
Adam Warren burst through the gap but Jarrod Evans recovered to make a try-saving tackle and while the Dragons retained possession and went over in the corner, the ball was held up.
The Dragons were awarded a penalty from the ensuing scrum and went to the corner. They went through the phases with a number of short balls off Sarel Pretorius until Rynard Landman powered over with Macleod converting.
It did not take long for them to stretch their lead further with the Blues unable to halt a powerful lineout with Elliot Dee rumbling over.
Former Cardiff Blues fly-half Macleod added the extras once again to bring the score to 17-0.
Wales’ Capital Region fought back but were unable to turn their pressure into points and went further behind when Adam Hughes intercepted Garyn Smith’s pass.
The Dragons wing raced under the sticks and Macleod made it 24-0 after 21 minutes.
They continued in the ascendant and claimed a fourth try through Nic Cudd following a Pretorius quick-tap penalty.
Macloed maintained his 100 per cent record with the boot making it 31-0 inside half an hour.
The Blues finally hit back on 35-minutes when Lewis Jones sniped over after a sustained period of pressure, in which James Sheekey carried to good affect.
Evans converted and the score remained 31-7 at the interval.
Thomas Rhys Thomas claimed a fifth try early in the second-half with Carl Meyer converting.
Cardiff Blues responded thanks to Shingler, who converted his own try on 58 minutes.
A long pass released Navidi on the left and Shingler snuck through the breakdown to race down the touchline.
Shingler bisected the posts and the Blues pounced for another try virtually straight from the restart with Navidi intercepting in midfield and showing impressive pace to score beneath the posts.
Shingler slotted the simple conversion to cut the deficit to 17-points. A stunning set-play, which then saw Dan Fish grubber through almost created a fourth try but the ball bounced cruelly away from Aled Summerhill, who won the foot race.
Both teams had chances in the final stages, as the game opened up, but it was Wales’ Capital Region that had the final say with Fish showing his devastating pace to collect Shingler’s clever kick through. Shingler converted to make it 38-28 at full-time.